• Introduction Ewing s sarcoma ES is a

  2019-05-10

  

  Introduction Ewing\'s sarcoma (ES) is a high-grade neoplasm representing the second most common primary bone malignancy in both children and adults. With a peak incidence at 15 years, this disease accounts for 2% of childhood cancers [1–3]. ES is defined as a bone tumor which may occur at any site

• br Future perspectives Identification of LOX as a

  2019-05-10

  

  Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “

• In a recent study Nademanee et

  2019-05-10

  

  In a recent study, Nademanee et al. [76]. reported additional evidence pointing to pathologic changes in the RVOT of patients with BrS that have proved undetectable by echocardiography or MRI. In contrast, imaging techniques in ARVC clearly display morphologic and functional changes (e.g., dilation

• La pol tica institucionalizada se convirti y se

  2019-05-10

  

  La política institucionalizada se convirtió y se aceptó, por parte de los actores relevantes del sistema (neo-oligarquías e instituciones), y en gran medida por lo benevolente y bondadosa que sería para los intereses del gran capital, como el vehículo hacia el futuro del Estado. Se decretó que la cr

• Interpretation Stakeholders from sectors not historically en

  2019-05-10

  

  Interpretation Stakeholders from sectors not historically engaged in health care are forming unique partnerships with common goals and a willingness to address the challenge of global cancer care. Funding None. Declaration of interests Abstract Background Since 2013 medical students from North

• br Case A year old man was referred

  2019-05-09

  

  Case A 45-year-old man was referred for the management of sudden-onset tachycardia. He had experienced 3 episodes of palpitation attacks, lasting for a couple of hours each, during the last 6 months. A regular, wide QRS complex tachycardia (WCT) at 150beats/min with a prominent retrograde P wave

• br To see how the quantity of osteosarcoma

  2019-05-09

  

  To see how the quantity of osteosarcoma in vitro studies developed overtime, we set out to systematically identify all the drugs that have been tested on osteosarcoma BMI-1 inhibitor in vitro in the past two decades. A PubMed search strategy was compiled which can be found in Supplementary data 1

• Automated template matching available in some electrophysiol

  2019-05-09

  

  Automated template matching, available in some electrophysiology systems, has been used to improve pace matching in the ventricle [13]. We found that using automated analysis improved the resolution of pace mapping, especially with bipolar EGMs. The matching algorithms are relatively simple and not

• Poor knowledge among caretakers of how to work with

  2019-05-09

  

  Poor knowledge among caretakers of how to work with disability-related disorders could also be an issue. For example, poor knowledge of how to correctly position a child with severe cerebral palsy could lead to inadequate feeding; at worst, these efforts can cause aspiration and even death. Social a

• br Results Karyotyping revealed chromosomal abnormalities in

  2019-05-09

  

  Results Karyotyping revealed chromosomal abnormalities in 19 of 20 metaphase spreads examined. All abnormal metaphases had a del(14)(q22), and 17 metaphases were interpreted to contain a three way translocation, t(2;5;7)(q31;q21;q11.2) and loss of all or part of chromosome 6. FISH analysis showed

• br Benefits and tips for antitachycardia pacing To

  2019-05-09

  

  Benefits and tips for antitachycardia pacing To reduce ICD shocks, antitachycardia pacing (ATP) for terminating lethal ventricular tachyarrhythmias must be programmed. There are 2 main types of ATP: burst (scan) pacing and autodecremental overdrive pacing (ramp pacing). Programming ATP is common

• Tasquinimod br Material and Methods br

  2019-05-09

  

  Material and Methods Results Discussion Radiofrequency ablation has a long history of use. It has been used especially in the neurosurgical field [8,9]. Rosenthal described the first ablations in bone 20 years ago [5]. Technically the radiofrequency generator forms an electric current leadi

• br Discussion CML was the first malignancy to

  2019-05-08

  

  Discussion CML was the first malignancy to be linked to a clear genetic abnormality, the Philadelphia chromosome. This chromosomal abnormality is so named because of the city in which it was first discovered and described in 1960 by Peter Nowell and David Hungerford [1]. The fusion protein result

• br Antimicrobial drugs are the most counterfeit or substanda

  2019-05-08

  

  Antimicrobial drugs are the most counterfeit or substandard drugs worldwide. The pharmacopoeial quality of these drugs in China is of special concern because China is the second producer, after India, of most counterfeit or substandard drugs in the global market. The antimicrobials circulating in

• HBV DNA levels are associated with clinically significant

  2019-05-08

  

  HBV DNA levels are associated with clinically significant pathological events, such as cirrhosis; therefore, changes in the serum levels of HBV DNA could determine a risk for hepatocellular carcinoma. For on-treatment follow-up, HBeAg loss/seroconversion is important during the nucleoside therapy fo

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